When I look at ACADIA Pharmaceuticals, I see a company that has already crossed one of biotechnology’s most dangerous borders: it has stopped being a clinical-stage promise factory and become a commercial business. That distinction matters. ACADIA has two approved products, growing revenue, positive net income, and enough cash to fund a serious development program without immediately passing a collection plate among shareholders. It also has a pipeline capable of changing the company’s long-term value—assuming, as always, that biology agrees to cooperate. That last condition deserves emphasis. Biotechnology investors have a charming habit of treating every clinical program as an approved blockbuster temporarily inconvenienced by the absence of evidence. A compound enters Phase 2, management displays an enormous patient population, and somebody multiplies that population by the annual treatment cost. By lunchtime, the drug is supposedly worth $12 billion. Actual drug development is less...