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Featured post

Accenture’s AI Opportunity Isn’t About Chatbots—It’s About Rebuilding Corporate America

Why I believe the real prize for Accenture is not selling companies another clever interface, but helping them reconstruct the machinery beneath the modern enterprise. When most people hear “artificial intelligence,” they still picture a chatbot. They imagine an employee typing a question into a box, getting a polished answer in seconds, and saving a little time on an email or presentation. That is the most visible expression of AI, so naturally it receives most of the attention. It is also, in my view, the least interesting part of the opportunity now sitting in front of Accenture. The chatbot is the showroom. The real business is behind the walls. Corporate America is full of old software, fragmented databases, manual approvals, conflicting policies, duplicated work, and systems that were never designed to communicate with one another. Many large companies have spent decades adding technology without removing much of what came before it. They operate with modern websites sitting on t...
Recent posts

ACADIA’s Rare-Disease Ambitions Could Reshape the Company’s Growth Profile

When I first look at ACADIA Pharmaceuticals, I see a company that has already accomplished something many biotechnology businesses never manage to do: It has moved beyond the PowerPoint stage. ACADIA has actual products, actual revenue, and actual patients using its medicines. That may sound like a low bar until I remember how many biotechnology companies spend years discussing enormous addressable markets while producing little besides clinical-trial expenses and increasingly imaginative investor presentations. ACADIA is different. NUPLAZID has established the company in Parkinson’s disease psychosis, while DAYBUE has given it a commercial position in Rett syndrome. Those two products generated combined second-quarter 2026 revenue of approximately $308 million. Management raised its full-year revenue guidance to between $1.24 billion and $1.30 billion, including projected DAYBUE sales of $480 million to $510 million and NUPLAZID sales of $760 million to $790 million. ACADIA’s second-q...

ACADIA’s Pipeline Math: What Future Indications Could Be Worth to Shareholders

When I look at ACADIA Pharmaceuticals, I see a company that has already crossed one of biotechnology’s most dangerous borders: it has stopped being a clinical-stage promise factory and become a commercial business. That distinction matters. ACADIA has two approved products, growing revenue, positive net income, and enough cash to fund a serious development program without immediately passing a collection plate among shareholders. It also has a pipeline capable of changing the company’s long-term value—assuming, as always, that biology agrees to cooperate. That last condition deserves emphasis. Biotechnology investors have a charming habit of treating every clinical program as an approved blockbuster temporarily inconvenienced by the absence of evidence. A compound enters Phase 2, management displays an enormous patient population, and somebody multiplies that population by the annual treatment cost. By lunchtime, the drug is supposedly worth $12 billion. Actual drug development is less...

ACADIA Pharmaceuticals Has Entered a New Chapter—Can Its Commercial Portfolio Deliver?

For years, I viewed ACADIA Pharmaceuticals as a company with one commercial engine and an uncomfortable amount of hope attached to everything else. That engine was NUPLAZID, the first and only drug approved in the United States for hallucinations and delusions associated with Parkinson’s disease psychosis. It gave ACADIA a real business, not merely a collection of laboratory ambitions. But it also made the investment story painfully concentrated. When one drug carries the company, every prescription trend, reimbursement change, patent dispute, and competitive threat begins to feel like a referendum on the entire enterprise. That is no longer the full story. DAYBUE, approved in 2023 for Rett syndrome, has become a meaningful second franchise. ACADIA now expects more than $1.2 billion in combined annual revenue from two approved medicines, has nearly $1 billion in cash and investments, and is generating quarterly profit while funding a broader neuroscience pipeline. The company has cross...